Dr. Simpson’s research program focuses on how to improve treatments for people with obsessive-compulsive disorder (OCD) and related disorders so that these people can live productive lives. Her research is interdisciplinary. It ranges from treatment development studies to clinical trials examining the effects of medication and cognitive-behavioral therapy to brain imaging studies exploring the brain mechanisms of OCD to animal studies in collaboration with basic scientists. Her work has been funded by two NARSAD Grants from the Brain & Behavior Research Foundation (2005 and 2010) and by the National Institutes of Mental Health. She was a member of the workgroup that developed the first Practice Guidelines for the Treatment of Patients with OCD for the American Psychiatric Association. She is an Advisor to the DSM-5 Workgroup on OCD and Related Disorders.