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Studying Ketamine’s Rapid Effects to Unlock Secrets for Developing Better Antidepressants

We offer A RESEARCHER’S PERSPECTIVE, based on a presentation given by Lisa M. Monteggia, Ph.D., of Vanderbilt University, at a zoom event hosted by BBRF. The topic of her presentation was “Studying Ketamine’s Rapid Effects to Unlock Secrets for Developing Better Antidepressants.” Dr. Monteggia reflects on what she has learned about antidepressant mechanisms from the therapeutic results obtained with the experimental drug ketamine.

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Accelerating Psychiatric Drug Development

Our PATHWAYS TO THE FUTURE story is about an unconventional approach to developing new psychiatric drugs. Based on an initiative by the National Institute of Mental Health, it’s called “Fast-Fail” and is designed to weed out the weakest drug candidates early in the process, to save time and money. In its first comprehensive test, a team led by two BBRF grantees and including 11 other BBRF grantees, Scientific Council members and prize winners, demonstrated the approach using a potential drug to treat anhedonia—the inability to experience or seek pleasure—which is seen in a number of psychiatric disorders including depression, anxiety, and PTSD.

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2020 International Mental Health Research Symposium Presentations

View all of the presentations from our 2020 International Mental Health Research Virtual Symposium including Dr. Myrna M. Weissman, Ph.D.'s Keynote Presentation and research updates from our Outstanding Achievement Prizewinners.

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‘An Epidemic of Loneliness and Despair’: How Wisdom Can Help

Q&A with Dilip Jeste, M.D., on the role of wisdom in dealing with what he has called “an epidemic of loneliness and despair” in America.

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2020 Pardes Humanitarian Prize in Mental Health Honors Global Advocates for the Poor and Children with Psychiatric Illness

Efforts by 2020 Pardes Prize honorees – Dr. Myrna Weissman, Sir Michael Rutter, and Dr. E. Fuller Torrey -- have had a profound impact on improving the lives of people with mental illness.

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