Brain and Behavior Research Foundation

Optogenetics: Decoding Brain Circuitry and How it Links to Behavior

Optogenetics: Decoding Brain Circuitry and How it Links to Behavior

Karl Deisseroth, M.D., Ph.D., used his 2005 NARSAD Young Investigator Grant to develop optogenetics, a new technology that has revolutionized systems neuroscience by providing precise control over brain circuitry in awake, behaving animals. Optogenetics involves the use of light to rapidly open and close the membrane channels that make neurons fire and cease firing and allows for observation of the effects on behavior.