Research suggesting significantly better outcomes in schizophrenia when it is treated early has led to efforts to provide coordinated, multispecialty care as soon as possible to individuals who experience a first episode of psychosis. The next advance with a potentially game-changing impact will be the development of reliable means of identifying and treating those at high risk prior to a first psychotic episode. I will discuss efforts to develop more precise diagnostic measures using biomarkers and innovative treatments for preventive intervention, research that could lead disease-modifying treatments.
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