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Next-Generation Therapies

Next-Generation Therapies

We invest in next-generation therapies to reduce symptoms of mental illness and ultimately prevent and cure brain and behavior disorders.

Discovery Articles

Experiments in Rodents Suggest Feasibility of Modifying or Erasing Traumatic Fear Memories

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Posted: Thursday, May 13, 2021

Experiments in Rodents Suggest Feasibility of Modifying or Erasing Traumatic Fear Memories

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Medicine to Treat Premenstrual Mood Disorder is Tested

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Posted: Thursday, May 6, 2021

Medicine to Treat Premenstrual Mood Disorder is Tested

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In Early Schizophrenia, Long-Acting Injectable Antipsychotic Treatment Lengthened Time to First Hospitalization

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Posted: Thursday, March 25, 2021

In Early Schizophrenia, Long-Acting Injectable Antipsychotic Treatment Lengthened Time to First Hospitalization

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In Major Depression, Accelerated rTMS Brain Stimulation Shows Promise

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Posted: Thursday, March 11, 2021

In Major Depression, Accelerated rTMS Brain Stimulation Shows Promise

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Brain-Wave Patterns Shed Light on Pathologies and New Treatments in Substance-Use Disorders

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Posted: Thursday, March 4, 2021

Brain-Wave Patterns Shed Light on Pathologies and New Treatments in Substance-Use Disorders

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Researchers Explore Whether L-DOPA Can Help PTSD Patients Learn to Extinguish Fear Memories

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Posted: Wednesday, February 24, 2021

Researchers Explore Whether L-DOPA Can Help PTSD Patients Learn to Extinguish Fear Memories

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In Schizophrenia, Differences in the Brain’s Energy Pathways Suggest Possible New Treatment Target

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Posted: Thursday, February 18, 2021

In Schizophrenia, Differences in the Brain’s Energy Pathways Suggest Possible New Treatment Target

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Combining the Antipsychotic Olanzapine with an Opioid-Receptor Blocker Significantly Limited Weight-Gain Risk in Schizophrenia Patients

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Posted: Thursday, January 28, 2021

Combining the Antipsychotic Olanzapine with an Opioid-Receptor Blocker Significantly Limited Weight-Gain Risk in Schizophrenia Patients

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Repeated Ketamine Infusions Over 2 Weeks Significantly Reduced Chronic PTSD Symptoms

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Posted: Thursday, January 14, 2021

Repeated Ketamine Infusions Over 2 Weeks Significantly Reduced Chronic PTSD Symptoms

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Psychosocial Interventions Are Found to Reduce Inflammation and Boost Beneficial Immune System Function

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Posted: Thursday, January 7, 2021

Psychosocial Interventions Are Found to Reduce Inflammation and Boost Beneficial Immune System Function

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Psychotherapy in Addition to Medication Helps Bipolar Disorder Patients Avoid Relapse and Manage Their Symptoms, Study Determines

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Posted: Thursday, November 19, 2020

Psychotherapy in Addition to Medication Helps Bipolar Disorder Patients Avoid Relapse and Manage Their Symptoms, Study Determines

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Unconscious Exposure to a Feared Stimulus Can Reduce Fear, Study Shows

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Posted: Thursday, November 5, 2020

Unconscious Exposure to a Feared Stimulus Can Reduce Fear, Study Shows

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Drugs Targeting the Glutamate System Warrant Continued Development for Schizophrenia, Study Finds

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Posted: Thursday, October 22, 2020

Drugs Targeting the Glutamate System Warrant Continued Development for Schizophrenia, Study Finds

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New Study Demonstrates Non-Invasive tDCS Brain Stimulation Can Enhance Cognitive Control in Schizophrenia Patients

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Posted: Thursday, October 8, 2020

New Study Demonstrates Non-Invasive tDCS Brain Stimulation Can Enhance Cognitive Control in Schizophrenia Patients

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Study Makes Case for Rigorous Re-Testing of Opioid Antagonists to Treat Schizophrenia

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Posted: Thursday, October 1, 2020

Study Makes Case for Rigorous Re-Testing of Opioid Antagonists to Treat Schizophrenia

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Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Posted: Thursday, September 24, 2020

Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Posted: Thursday, August 27, 2020

Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Posted: Tuesday, August 11, 2020

Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Non-Invasive Brain Stimulation Continued to Help Veterans with PTSD a Year After Treatment

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Posted: Wednesday, August 5, 2020

Non-Invasive Brain Stimulation Continued to Help Veterans with PTSD a Year After Treatment

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Non-invasive Brain Stimulation Reduced Fear and Anxiety in a Preliminary Trial

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Posted: Wednesday, July 29, 2020

Non-invasive Brain Stimulation Reduced Fear and Anxiety in a Preliminary Trial

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Identifying Brain Connectivity Changes in Combat Veterans with PTSD

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Posted: Wednesday, July 22, 2020

Identifying Brain Connectivity Changes in Combat Veterans with PTSD

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Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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Posted: Thursday, June 18, 2020

Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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In 2 Trials, Ketamine Plus Behavioral Therapies Helped People with Cocaine and Alcohol Dependencies to Abstain

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Posted: Thursday, May 28, 2020

In 2 Trials, Ketamine Plus Behavioral Therapies Helped People with Cocaine and Alcohol Dependencies to Abstain

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In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Posted: Thursday, May 14, 2020

In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Clinical Trial Measures Impact of Combining Cognitive Training with Drug Treatment in Age-Related Cognitive Decline

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Posted: Thursday, May 7, 2020

Clinical Trial Measures Impact of Combining Cognitive Training with Drug Treatment in Age-Related Cognitive Decline

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Study of Loneliness in a Senior Housing Community Points to Risk and Potential Protective Factors

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Posted: Thursday, April 2, 2020

Study of Loneliness in a Senior Housing Community Points to Risk and Potential Protective Factors

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Progress is Reported on Research Exploring Use of Deep-Brain Stimulation for Psychosis, Schizophrenia

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Posted: Thursday, March 26, 2020

Progress is Reported on Research Exploring Use of Deep-Brain Stimulation for Psychosis, Schizophrenia

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Adding Ambien to an SSRI Antidepressant Could Help Some Depressed Patients with Severe Insomnia

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Posted: Thursday, March 19, 2020

Adding Ambien to an SSRI Antidepressant Could Help Some Depressed Patients with Severe Insomnia

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Activating Specific Serotonin Neurons Reduced Anxiety and Promoted Sleep in Mice

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Posted: Thursday, March 5, 2020

Activating Specific Serotonin Neurons Reduced Anxiety and Promoted Sleep in Mice

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New Approach to Lessen Negative Symptoms in Schizophrenia is Based on Brain Circuit Discovery

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Posted: Thursday, January 16, 2020

New Approach to Lessen Negative Symptoms in Schizophrenia is Based on Brain Circuit Discovery

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Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Posted: Thursday, October 17, 2019

Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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Posted: Thursday, October 10, 2019

Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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