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Next-Generation Therapies

Next-Generation Therapies

We invest in next-generation therapies to reduce symptoms of mental illness and ultimately prevent and cure brain and behavior disorders.

Discovery Articles

Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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Posted: Thursday, June 18, 2020

Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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In 2 Trials, Ketamine Plus Behavioral Therapies Helped People with Cocaine and Alcohol Dependencies to Abstain

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Posted: Thursday, May 28, 2020

In 2 Trials, Ketamine Plus Behavioral Therapies Helped People with Cocaine and Alcohol Dependencies to Abstain

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In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Posted: Thursday, May 14, 2020

In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Clinical Trial Measures Impact of Combining Cognitive Training with Drug Treatment in Age-Related Cognitive Decline

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Posted: Thursday, May 7, 2020

Clinical Trial Measures Impact of Combining Cognitive Training with Drug Treatment in Age-Related Cognitive Decline

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Study of Loneliness in a Senior Housing Community Points to Risk and Potential Protective Factors

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Posted: Thursday, April 2, 2020

Study of Loneliness in a Senior Housing Community Points to Risk and Potential Protective Factors

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Progress is Reported on Research Exploring Use of Deep-Brain Stimulation for Psychosis, Schizophrenia

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Posted: Thursday, March 26, 2020

Progress is Reported on Research Exploring Use of Deep-Brain Stimulation for Psychosis, Schizophrenia

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Adding Ambien to an SSRI Antidepressant Could Help Some Depressed Patients with Severe Insomnia

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Posted: Thursday, March 19, 2020

Adding Ambien to an SSRI Antidepressant Could Help Some Depressed Patients with Severe Insomnia

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Activating Specific Serotonin Neurons Reduced Anxiety and Promoted Sleep in Mice

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Posted: Thursday, March 5, 2020

Activating Specific Serotonin Neurons Reduced Anxiety and Promoted Sleep in Mice

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New Approach to Lessen Negative Symptoms in Schizophrenia is Based on Brain Circuit Discovery

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Posted: Thursday, January 16, 2020

New Approach to Lessen Negative Symptoms in Schizophrenia is Based on Brain Circuit Discovery

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Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Posted: Thursday, October 17, 2019

Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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Posted: Thursday, October 10, 2019

Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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Potential Biomarker May Predict Which Depressed Patients Getting CBT Will Have Added Benefit from tDCS Brain Stimulation

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Posted: Thursday, September 26, 2019

Potential Biomarker May Predict Which Depressed Patients Getting CBT Will Have Added Benefit from tDCS Brain Stimulation

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Non-Invasive Brain Stimulation May Help Some OCD Patients Who Don’t Respond to Medications or Psychotherapy

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Posted: Thursday, September 12, 2019

Non-Invasive Brain Stimulation May Help Some OCD Patients Who Don’t Respond to Medications or Psychotherapy

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Large Genome Study Suggests Anorexia Nervosa is a Metabolic Disorder as Well as a Psychiatric One

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Posted: Thursday, August 22, 2019

Large Genome Study Suggests Anorexia Nervosa is a Metabolic Disorder as Well as a Psychiatric One

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Study Finds Lithium Has Advantages Over Other Mood Stabilizers in Youths with Bipolar Disorder

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Posted: Thursday, August 15, 2019

Study Finds Lithium Has Advantages Over Other Mood Stabilizers in Youths with Bipolar Disorder

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RESEARCH FOR RECOVERY: Advances in Cognitive Remediation: ‘Helping Schizophrenia Patients Who Need It Most’

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Posted: Sunday, June 30, 2019

RESEARCH FOR RECOVERY: Advances in Cognitive Remediation: ‘Helping Schizophrenia Patients Who Need It Most’

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FDA Approves Cariprazine for Depression in Bipolar I Disorder

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Posted: Thursday, June 20, 2019

FDA Approves Cariprazine for Depression in Bipolar I Disorder

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Early-Morning Bright-Light Therapy Helped Patients with PTSD Symptoms

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Posted: Wednesday, May 8, 2019

Early-Morning Bright-Light Therapy Helped Patients with PTSD Symptoms

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Study: Ketamine Restores Neural Connection Points Lost in Stress & Depression

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Posted: Thursday, May 2, 2019

Study: Ketamine Restores Neural Connection Points Lost in Stress & Depression

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Different Response Patterns to TMS Treatment for Major Depression Point to Possibility of Individualized Treatments

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Posted: Thursday, April 25, 2019

Different Response Patterns to TMS Treatment for Major Depression Point to Possibility of Individualized Treatments

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In a Comparison of Two Kinds of Cognitive Training, One Appeared to Help Schizophrenia Patients More

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Posted: Tuesday, April 9, 2019

In a Comparison of Two Kinds of Cognitive Training, One Appeared to Help Schizophrenia Patients More

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Opioids, at Very Low Doses, May Provide a New Way to Treat Resistant Depression

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Posted: Sunday, March 31, 2019

Opioids, at Very Low Doses, May Provide a New Way to Treat Resistant Depression

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Pioneering TMS Therapy for Depression

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Posted: Sunday, March 31, 2019

Pioneering TMS Therapy for Depression

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What Is Transcranial Magnetic Stimulation (TMS) Treatment and How Well does It Work?

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Posted: Sunday, March 31, 2019

What Is Transcranial Magnetic Stimulation (TMS) Treatment and How Well Does It Work?

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The First Drug Treatment To Specifically Relieve Postpartum Depression Is Approved

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Posted: Tuesday, March 26, 2019

The First Drug Treatment To Specifically Relieve Postpartum Depression Is Approved

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A Medicine That Treats Mania Also Shows Effectiveness in Treating Depression in Bipolar Disorder

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Posted: Tuesday, March 19, 2019

A Medicine That Treats Mania Also Shows Effectiveness in Treating Depression in Bipolar Disorder

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Researchers Explore How Adolescent Chronic Cannabis Use Could Affect Adult Memory

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Posted: Tuesday, February 19, 2019

Researchers Explore How Adolescent Chronic Cannabis Use Could Affect Adult Memory

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Advisory Panel Recommends FDA Approval of Esketamine , with New Mechanism to Treat Resistant Depression & Suicidal Thinking

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Posted: Thursday, February 14, 2019

Advisory Panel Recommends FDA Approval of Esketamine, with New Mechanism to Treat Resistant Depression

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Adding Guanfacine Boosted Benefits of Cognitive Remediation Therapy in Schizophrenia Spectrum Disorder

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Posted: Wednesday, January 30, 2019

Adding Guanfacine Boosted Benefits of Cognitive Remediation Therapy in Schizophrenia Spectrum Disorder

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More Rapid Form of Brain Stimulation for Resistant Depression Worked as Well as Conventional TMS

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Posted: Monday, December 3, 2018

More Rapid Form of Brain Stimulation for Resistant Depression Worked as Well as Conventional TMS

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Seeking the Optimal Dose for Ketamine’s Short-Term Rapid Antidepressant Effects

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Posted: Tuesday, November 27, 2018

Seeking the Optimal Dose for Ketamine’s Short-Term Rapid Antidepressant Effects

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New Clues for Medication to Prevent Disorders Caused by Early-Life Stress

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Posted: Tuesday, November 13, 2018

New Clues for Medications to Prevent Disorders Caused by Early-Life Stress

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