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Next-Generation Therapies

Next-Generation Therapies

We invest in next-generation therapies to reduce symptoms of mental illness and ultimately prevent and cure brain and behavior disorders.

Discovery Articles

In Pilot Study, Oxygen Therapy for Moderate Depression Showed Beneficial Effects

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Posted: Thursday, January 6, 2022

In Pilot Study, Oxygen Therapy for Moderate Depression Showed Beneficial Effects

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Two Signaling Pathways Involved in Regulating Synaptic Plasticity Suggest Novel Targets for Rapid-Acting Antidepressants

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Posted: Thursday, December 2, 2021

Two Signaling Pathways Involved in Regulating Synaptic Plasticity Suggest Novel Targets for Rapid-Acting Antidepressants

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Non-Invasive Brain-Stimulation Protocol for Treatment-Resistant Depression Enabled 79% to Experience Remission Following 5-Day Treatment Course

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Posted: Thursday, November 11, 2021

Non-Invasive Brain-Stimulation Protocol for Treatment-Resistant Depression Enabled 79% to Experience Remission Following 5-Day Treatment Course

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Lumateperone, an Antipsychotic, is Tested in a Phase 3 Trial for Major Depressive Episodes in Bipolar I and II Disorders

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Posted: Thursday, November 4, 2021

Lumateperone, an Antipsychotic, is Tested in a Phase 3 Trial for Major Depressive Episodes in Bipolar I and II Disorders

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Positive Preliminary Results in Highly Personalized Deep-Brain Stimulation Therapy for Treatment-Resistant Depression

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Posted: Thursday, October 28, 2021

Positive Preliminary Results in Highly Personalized Deep-Brain Stimulation Therapy for Treatment-Resistant Depression

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Mindfulness Training Plus tDCS Stimulation to Treat Cognitive Decline in Older Persons with Depression or Anxiety

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Posted: Thursday, October 21, 2021

Mindfulness Training Plus tDCS Stimulation to Treat Cognitive Decline in Older Persons with Depression or Anxiety

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New Treatment Approach for Alcohol Use Disorder is Tested in Animals

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Posted: Thursday, October 14, 2021

New Treatment Approach for Alcohol Use Disorder is Tested in Animals

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Study Indicates Brain Lesions and Treatment Targets in Depression Affect the Same Circuitry, Suggesting New Treatment Possibilities

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Posted: Thursday, August 5, 2021

Study Indicates Brain Lesions and Treatment Targets in Depression Affect the Same Circuitry, Suggesting New Treatment Possibilities

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Positive Phase 3 Test of Rapid-Acting Oral Medicine for Postpartum Depression

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Posted: Wednesday, July 14, 2021

Positive Phase 3 Test of Rapid-Acting Oral Medicine for Postpartum Depression

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Study Links Schizophrenia Medicines’ Anticholinergic Impact to Risk of Cognitive Impairment

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Posted: Thursday, July 1, 2021

Study Links Schizophrenia Medicines’ Anticholinergic Impact to Risk of Cognitive Impairment

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Positive Results in Trial Testing ‘Laughing Gas’ in Severely Depressed Treatment-Resistant Patients

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Posted: Thursday, June 17, 2021

Positive Results in Trial Testing ‘Laughing Gas’ in Severely Depressed Treatment-Resistant Patients

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Postpartum CBT for Depressed Moms May Help Lower Emotion-Regulation Risks in Infants

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Posted: Thursday, June 10, 2021

Postpartum CBT for Depressed Moms May Help Lower Emotion-Regulation Risks in Infants

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Experiments in Rodents Suggest Feasibility of Modifying or Erasing Traumatic Fear Memories

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Posted: Thursday, May 13, 2021

Experiments in Rodents Suggest Feasibility of Modifying or Erasing Traumatic Fear Memories

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Medicine to Treat Premenstrual Mood Disorder is Tested

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Posted: Thursday, May 6, 2021

Medicine to Treat Premenstrual Mood Disorder is Tested

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In Early Schizophrenia, Long-Acting Injectable Antipsychotic Treatment Lengthened Time to First Hospitalization

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Posted: Thursday, March 25, 2021

In Early Schizophrenia, Long-Acting Injectable Antipsychotic Treatment Lengthened Time to First Hospitalization

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In Major Depression, Accelerated rTMS Brain Stimulation Shows Promise

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Posted: Thursday, March 11, 2021

In Major Depression, Accelerated rTMS Brain Stimulation Shows Promise

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Brain-Wave Patterns Shed Light on Pathologies and New Treatments in Substance-Use Disorders

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Posted: Thursday, March 4, 2021

Brain-Wave Patterns Shed Light on Pathologies and New Treatments in Substance-Use Disorders

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Researchers Explore Whether L-DOPA Can Help PTSD Patients Learn to Extinguish Fear Memories

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Posted: Wednesday, February 24, 2021

Researchers Explore Whether L-DOPA Can Help PTSD Patients Learn to Extinguish Fear Memories

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In Schizophrenia, Differences in the Brain’s Energy Pathways Suggest Possible New Treatment Target

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Posted: Thursday, February 18, 2021

In Schizophrenia, Differences in the Brain’s Energy Pathways Suggest Possible New Treatment Target

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Combining the Antipsychotic Olanzapine with an Opioid-Receptor Blocker Significantly Limited Weight-Gain Risk in Schizophrenia Patients

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Posted: Thursday, January 28, 2021

Combining the Antipsychotic Olanzapine with an Opioid-Receptor Blocker Significantly Limited Weight-Gain Risk in Schizophrenia Patients

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Repeated Ketamine Infusions Over 2 Weeks Significantly Reduced Chronic PTSD Symptoms

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Posted: Thursday, January 14, 2021

Repeated Ketamine Infusions Over 2 Weeks Significantly Reduced Chronic PTSD Symptoms

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Psychosocial Interventions Are Found to Reduce Inflammation and Boost Beneficial Immune System Function

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Posted: Thursday, January 7, 2021

Psychosocial Interventions Are Found to Reduce Inflammation and Boost Beneficial Immune System Function

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Psychotherapy in Addition to Medication Helps Bipolar Disorder Patients Avoid Relapse and Manage Their Symptoms, Study Determines

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Posted: Thursday, November 19, 2020

Psychotherapy in Addition to Medication Helps Bipolar Disorder Patients Avoid Relapse and Manage Their Symptoms, Study Determines

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Unconscious Exposure to a Feared Stimulus Can Reduce Fear, Study Shows

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Posted: Thursday, November 5, 2020

Unconscious Exposure to a Feared Stimulus Can Reduce Fear, Study Shows

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Drugs Targeting the Glutamate System Warrant Continued Development for Schizophrenia, Study Finds

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Posted: Thursday, October 22, 2020

Drugs Targeting the Glutamate System Warrant Continued Development for Schizophrenia, Study Finds

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New Study Demonstrates Non-Invasive tDCS Brain Stimulation Can Enhance Cognitive Control in Schizophrenia Patients

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Posted: Thursday, October 8, 2020

New Study Demonstrates Non-Invasive tDCS Brain Stimulation Can Enhance Cognitive Control in Schizophrenia Patients

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Study Makes Case for Rigorous Re-Testing of Opioid Antagonists to Treat Schizophrenia

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Posted: Thursday, October 1, 2020

Study Makes Case for Rigorous Re-Testing of Opioid Antagonists to Treat Schizophrenia

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Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Posted: Thursday, September 24, 2020

Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Posted: Thursday, August 27, 2020

Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Posted: Tuesday, August 11, 2020

Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Non-Invasive Brain Stimulation Continued to Help Veterans with PTSD a Year After Treatment

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Posted: Wednesday, August 5, 2020

Non-Invasive Brain Stimulation Continued to Help Veterans with PTSD a Year After Treatment

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Non-invasive Brain Stimulation Reduced Fear and Anxiety in a Preliminary Trial

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Posted: Wednesday, July 29, 2020

Non-invasive Brain Stimulation Reduced Fear and Anxiety in a Preliminary Trial

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