Next-Generation Therapies

Discovery Articles

Video Game-Based Intervention Helped Reduce Cognitive Deficits in Depressed Patients

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Posted: Thursday, November 17, 2022

Video Game-Based Intervention Helped Reduce Cognitive Deficits in Depressed Patients

Clinical Trial Compared Different Forms of Exposure and Drug Therapy in Combat Veterans with PTSD

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Posted: Thursday, November 10, 2022

Clinical Trial Compared Different Forms of Exposure and Drug Therapy in Combat Veterans with PTSD

Adding an Antibiotic Improved Brain Stimulation Results in Depression

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Posted: Thursday, November 3, 2022

Adding an Antibiotic Improved Brain Stimulation Results in Depression

After ‘Priming’ with Ketamine, Patients Receiving Self-Esteem Training Had Extended Antidepressant Benefits, Study Finds

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Posted: Thursday, October 20, 2022

After ‘Priming’ with Ketamine, Patients Receiving Self-Esteem Training Had Extended Antidepressant Benefits, Study Finds

Folic Acid Supplements Were Associated With Lower Suicidality in Large Database Study

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Posted: Thursday, October 13, 2022

Folic Acid Supplements Were Associated With Lower Suicidality in Large Database Study

Two Forms of Non-Invasive Brain Stimulation Helped Older Adults with Treatment-Resistant Depression

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Posted: Thursday, October 6, 2022

Two Forms of Non-Invasive Brain Stimulation Helped Older Adults with Treatment-Resistant Depression

FDA Clears SAINT Rapid-Acting Brain Stimulation Approach for Those Suffering From Resistant Major Depression

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Posted: Thursday, September 15, 2022

FDA Clears SAINT Rapid-Acting Brain Stimulation Approach for Those Suffering From Resistant Major Depression

The last decade has seen a vast increase in the use of brain stimulation technologies to reduce symptoms of psychiatric illness. By far the most influential has been TMS, a non-invasive method employing magnets that generate electric fields which are thought to therapeutically alter the activity of neurons and brain circuits involved in depression and other disorders. TMS was pioneered by BBRF Scientific Council member Mark S. George, M.D., who used two early-career BBRF grants to develop the protocol ul

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Posted: Thursday, August 25, 2022

Team Assesses Safety of t-PBM, Non-Invasive Brain Stimulation Technology That Uses Light to Treat Depression and Anxiety

Comprehensive Analysis Suggests Metacognitive Training Can Be Effective in Schizophrenia and Psychotic Disorders

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Posted: Wednesday, July 20, 2022

Comprehensive Analysis Suggests Metacognitive Training Can Be Effective in Schizophrenia and Psychotic Disorders

1-Day Online CBT-Based Workshop Helped New Moms With Postpartum Depression

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Posted: Tuesday, July 12, 2022

1-Day Online CBT-Based Workshop Helped New Moms With Postpartum Depression

Some OCD Patients Who Attain “Wellness” After Exposure Therapy May Safely Taper Off Their SRI Medicines, Study Suggests

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Posted: Thursday, July 7, 2022

Some OCD Patients Who Attain “Wellness” After Exposure Therapy May Safely Taper Off Their SRI Medicines, Study Suggests

A Circuit Causally Linked With Spontaneous Nicotine Addiction Remissions May Be a Powerful Addiction Treatment Target

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Posted: Thursday, June 30, 2022

A Circuit Causally Linked With Spontaneous Nicotine Addiction Remissions May Be a Powerful Addiction Treatment Target

Researchers Discover Potentially Targetable Brain Circuit Controlling Cocaine Withdrawal Anxiety and Relapse

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Posted: Thursday, June 16, 2022

Researchers Discover Potentially Targetable Brain Circuit Controlling Cocaine Withdrawal Anxiety and Relapse

Combining Antidepressants Can Improve Outcomes in Patients with Severe Depression, Study Finds

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Posted: Thursday, June 9, 2022

Combining Antidepressants Can Improve Outcomes in Patients with Severe Depression, Study Finds

A Molecule Tested in Higher Primates Reduced Alcohol Consumption By Half

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Posted: Thursday, May 26, 2022

A Molecule Tested in Higher Primates Reduced Alcohol Consumption By Half

Stem Cell Technology Helps Identify a Potential Causal Mechanism in Schizophrenia That Could Be Targeted

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Posted: Thursday, May 5, 2022

Stem Cell Technology Helps Identify a Potential Causal Mechanism in Schizophrenia That Could Be Targeted

New Insights About Epilepsy Mechanism Suggest a Potential Treatment Target

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Posted: Thursday, April 28, 2022

New Insights About Epilepsy Mechanism Suggest a Potential Treatment Target

Team Tests Model to Enable More Effective Targeting of Non-Invasive TMS Treatments in Depression

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Posted: Thursday, April 21, 2022

Team Tests Model to Enable More Effective Targeting of Non-Invasive TMS Treatments in Depression

Imaging Analysis Suggests How Ketamine Treatment Might Have Helped Reduce Chronic PTSD Symptoms in Trial Subjects

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Posted: Thursday, April 14, 2022

Imaging Analysis Suggests How Ketamine Treatment Might Have Helped Reduce Chronic PTSD Symptoms in Trial Subjects

Team Uses Non-Invasive TMS Brain Stimulation to Activate Deep-Brain Region Important in Depression

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Posted: Thursday, April 7, 2022

Team Uses Non-Invasive TMS Brain Stimulation to Activate Deep-Brain Region Important in Depression

Adding Lithium Might Enable Ketamine's Antidepressant Activity in Ketamine-Resistant Patients, Study Suggests

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Posted: Thursday, March 3, 2022

Adding Lithium Might Enable Ketamine's Antidepressant Activity in Ketamine-Resistant Patients, Study Suggests

Discovering How tDCS Brain Stimulation Therapeutically Modifies Brain Circuits in Depression

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Posted: Thursday, February 17, 2022

Discovering How tDCS Brain Stimulation Therapeutically Modifies Brain Circuits in Depression

Evidence That Cognitive Behavioral Therapy Can Help People With Insomnia Who Also Are Depressed or Anxious

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Posted: Thursday, February 10, 2022

Evidence That Cognitive Behavioral Therapy Can Help People With Insomnia Who Also Are Depressed or Anxious

In Pilot Study, Oxygen Therapy for Moderate Depression Showed Beneficial Effects

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Posted: Thursday, January 6, 2022

In Pilot Study, Oxygen Therapy for Moderate Depression Showed Beneficial Effects

Two Signaling Pathways Involved in Regulating Synaptic Plasticity Suggest Novel Targets for Rapid-Acting Antidepressants

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Posted: Thursday, December 2, 2021

Two Signaling Pathways Involved in Regulating Synaptic Plasticity Suggest Novel Targets for Rapid-Acting Antidepressants

Non-Invasive Brain-Stimulation Protocol for Treatment-Resistant Depression Enabled 79% to Experience Remission Following 5-Day Treatment Course

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Posted: Thursday, November 11, 2021

Non-Invasive Brain-Stimulation Protocol for Treatment-Resistant Depression Enabled 79% to Experience Remission Following 5-Day Treatment Course

Lumateperone, an Antipsychotic, is Tested in a Phase 3 Trial for Major Depressive Episodes in Bipolar I and II Disorders

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Posted: Thursday, November 4, 2021

Lumateperone, an Antipsychotic, is Tested in a Phase 3 Trial for Major Depressive Episodes in Bipolar I and II Disorders

Positive Preliminary Results in Highly Personalized Deep-Brain Stimulation Therapy for Treatment-Resistant Depression

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Posted: Thursday, October 28, 2021

Positive Preliminary Results in Highly Personalized Deep-Brain Stimulation Therapy for Treatment-Resistant Depression

Mindfulness Training Plus tDCS Stimulation to Treat Cognitive Decline in Older Persons with Depression or Anxiety

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Posted: Thursday, October 21, 2021

Mindfulness Training Plus tDCS Stimulation to Treat Cognitive Decline in Older Persons with Depression or Anxiety

New Treatment Approach for Alcohol Use Disorder is Tested in Animals

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Posted: Thursday, October 14, 2021

New Treatment Approach for Alcohol Use Disorder is Tested in Animals

Study Indicates Brain Lesions and Treatment Targets in Depression Affect the Same Circuitry, Suggesting New Treatment Possibilities

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Posted: Thursday, August 5, 2021

Study Indicates Brain Lesions and Treatment Targets in Depression Affect the Same Circuitry, Suggesting New Treatment Possibilities

Positive Phase 3 Test of Rapid-Acting Oral Medicine for Postpartum Depression

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Posted: Wednesday, July 14, 2021

Positive Phase 3 Test of Rapid-Acting Oral Medicine for Postpartum Depression

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Next-Generation Therapies