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Next-Generation Therapies

Next-Generation Therapies

We invest in next-generation therapies to reduce symptoms of mental illness and ultimately prevent and cure brain and behavior disorders.

Discovery Articles

Mindfulness Training Plus tDCS Stimulation to Treat Cognitive Decline in Older Persons with Depression or Anxiety

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Posted: Thursday, October 21, 2021

Mindfulness Training Plus tDCS Stimulation to Treat Cognitive Decline in Older Persons with Depression or Anxiety

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New Treatment Approach for Alcohol Use Disorder is Tested in Animals

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Posted: Thursday, October 14, 2021

New Treatment Approach for Alcohol Use Disorder is Tested in Animals

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Study Indicates Brain Lesions and Treatment Targets in Depression Affect the Same Circuitry, Suggesting New Treatment Possibilities

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Posted: Thursday, August 5, 2021

Study Indicates Brain Lesions and Treatment Targets in Depression Affect the Same Circuitry, Suggesting New Treatment Possibilities

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Positive Phase 3 Test of Rapid-Acting Oral Medicine for Postpartum Depression

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Posted: Wednesday, July 14, 2021

Positive Phase 3 Test of Rapid-Acting Oral Medicine for Postpartum Depression

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Study Links Schizophrenia Medicines’ Anticholinergic Impact to Risk of Cognitive Impairment

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Posted: Thursday, July 1, 2021

Study Links Schizophrenia Medicines’ Anticholinergic Impact to Risk of Cognitive Impairment

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Positive Results in Trial Testing ‘Laughing Gas’ in Severely Depressed Treatment-Resistant Patients

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Posted: Thursday, June 17, 2021

Positive Results in Trial Testing ‘Laughing Gas’ in Severely Depressed Treatment-Resistant Patients

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Postpartum CBT for Depressed Moms May Help Lower Emotion-Regulation Risks in Infants

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Posted: Thursday, June 10, 2021

Postpartum CBT for Depressed Moms May Help Lower Emotion-Regulation Risks in Infants

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Experiments in Rodents Suggest Feasibility of Modifying or Erasing Traumatic Fear Memories

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Posted: Thursday, May 13, 2021

Experiments in Rodents Suggest Feasibility of Modifying or Erasing Traumatic Fear Memories

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Medicine to Treat Premenstrual Mood Disorder is Tested

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Posted: Thursday, May 6, 2021

Medicine to Treat Premenstrual Mood Disorder is Tested

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In Early Schizophrenia, Long-Acting Injectable Antipsychotic Treatment Lengthened Time to First Hospitalization

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Posted: Thursday, March 25, 2021

In Early Schizophrenia, Long-Acting Injectable Antipsychotic Treatment Lengthened Time to First Hospitalization

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In Major Depression, Accelerated rTMS Brain Stimulation Shows Promise

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Posted: Thursday, March 11, 2021

In Major Depression, Accelerated rTMS Brain Stimulation Shows Promise

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Brain-Wave Patterns Shed Light on Pathologies and New Treatments in Substance-Use Disorders

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Posted: Thursday, March 4, 2021

Brain-Wave Patterns Shed Light on Pathologies and New Treatments in Substance-Use Disorders

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Researchers Explore Whether L-DOPA Can Help PTSD Patients Learn to Extinguish Fear Memories

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Posted: Wednesday, February 24, 2021

Researchers Explore Whether L-DOPA Can Help PTSD Patients Learn to Extinguish Fear Memories

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In Schizophrenia, Differences in the Brain’s Energy Pathways Suggest Possible New Treatment Target

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Posted: Thursday, February 18, 2021

In Schizophrenia, Differences in the Brain’s Energy Pathways Suggest Possible New Treatment Target

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Combining the Antipsychotic Olanzapine with an Opioid-Receptor Blocker Significantly Limited Weight-Gain Risk in Schizophrenia Patients

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Posted: Thursday, January 28, 2021

Combining the Antipsychotic Olanzapine with an Opioid-Receptor Blocker Significantly Limited Weight-Gain Risk in Schizophrenia Patients

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Repeated Ketamine Infusions Over 2 Weeks Significantly Reduced Chronic PTSD Symptoms

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Posted: Thursday, January 14, 2021

Repeated Ketamine Infusions Over 2 Weeks Significantly Reduced Chronic PTSD Symptoms

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Psychosocial Interventions Are Found to Reduce Inflammation and Boost Beneficial Immune System Function

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Posted: Thursday, January 7, 2021

Psychosocial Interventions Are Found to Reduce Inflammation and Boost Beneficial Immune System Function

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Psychotherapy in Addition to Medication Helps Bipolar Disorder Patients Avoid Relapse and Manage Their Symptoms, Study Determines

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Posted: Thursday, November 19, 2020

Psychotherapy in Addition to Medication Helps Bipolar Disorder Patients Avoid Relapse and Manage Their Symptoms, Study Determines

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Unconscious Exposure to a Feared Stimulus Can Reduce Fear, Study Shows

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Posted: Thursday, November 5, 2020

Unconscious Exposure to a Feared Stimulus Can Reduce Fear, Study Shows

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Drugs Targeting the Glutamate System Warrant Continued Development for Schizophrenia, Study Finds

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Posted: Thursday, October 22, 2020

Drugs Targeting the Glutamate System Warrant Continued Development for Schizophrenia, Study Finds

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New Study Demonstrates Non-Invasive tDCS Brain Stimulation Can Enhance Cognitive Control in Schizophrenia Patients

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Posted: Thursday, October 8, 2020

New Study Demonstrates Non-Invasive tDCS Brain Stimulation Can Enhance Cognitive Control in Schizophrenia Patients

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Study Makes Case for Rigorous Re-Testing of Opioid Antagonists to Treat Schizophrenia

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Posted: Thursday, October 1, 2020

Study Makes Case for Rigorous Re-Testing of Opioid Antagonists to Treat Schizophrenia

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Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Posted: Thursday, September 24, 2020

Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Posted: Thursday, August 27, 2020

Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Posted: Tuesday, August 11, 2020

Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Non-Invasive Brain Stimulation Continued to Help Veterans with PTSD a Year After Treatment

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Posted: Wednesday, August 5, 2020

Non-Invasive Brain Stimulation Continued to Help Veterans with PTSD a Year After Treatment

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Non-invasive Brain Stimulation Reduced Fear and Anxiety in a Preliminary Trial

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Posted: Wednesday, July 29, 2020

Non-invasive Brain Stimulation Reduced Fear and Anxiety in a Preliminary Trial

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Identifying Brain Connectivity Changes in Combat Veterans with PTSD

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Posted: Wednesday, July 22, 2020

Identifying Brain Connectivity Changes in Combat Veterans with PTSD

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Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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Posted: Thursday, June 18, 2020

Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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In 2 Trials, Ketamine Plus Behavioral Therapies Helped People with Cocaine and Alcohol Dependencies to Abstain

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Posted: Thursday, May 28, 2020

In 2 Trials, Ketamine Plus Behavioral Therapies Helped People with Cocaine and Alcohol Dependencies to Abstain

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In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Posted: Thursday, May 14, 2020

In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Clinical Trial Measures Impact of Combining Cognitive Training with Drug Treatment in Age-Related Cognitive Decline

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Posted: Thursday, May 7, 2020

Clinical Trial Measures Impact of Combining Cognitive Training with Drug Treatment in Age-Related Cognitive Decline

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