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Next-Generation Therapies

Next-Generation Therapies

We invest in next-generation therapies to reduce symptoms of mental illness and ultimately prevent and cure brain and behavior disorders.

Discovery Articles

Brain-Wave Patterns Shed Light on Pathologies and New Treatments in Substance-Use Disorders

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Posted: Thursday, March 4, 2021

Brain-Wave Patterns Shed Light on Pathologies and New Treatments in Substance-Use Disorders

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Researchers Explore Whether L-DOPA Can Help PTSD Patients Learn to Extinguish Fear Memories

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Posted: Wednesday, February 24, 2021

Researchers Explore Whether L-DOPA Can Help PTSD Patients Learn to Extinguish Fear Memories

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In Schizophrenia, Differences in the Brain’s Energy Pathways Suggest Possible New Treatment Target

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Posted: Thursday, February 18, 2021

In Schizophrenia, Differences in the Brain’s Energy Pathways Suggest Possible New Treatment Target

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Combining the Antipsychotic Olanzapine with an Opioid-Receptor Blocker Significantly Limited Weight-Gain Risk in Schizophrenia Patients

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Posted: Thursday, January 28, 2021

Combining the Antipsychotic Olanzapine with an Opioid-Receptor Blocker Significantly Limited Weight-Gain Risk in Schizophrenia Patients

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Repeated Ketamine Infusions Over 2 Weeks Significantly Reduced Chronic PTSD Symptoms

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Posted: Thursday, January 14, 2021

Repeated Ketamine Infusions Over 2 Weeks Significantly Reduced Chronic PTSD Symptoms

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Psychosocial Interventions Are Found to Reduce Inflammation and Boost Beneficial Immune System Function

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Posted: Thursday, January 7, 2021

Psychosocial Interventions Are Found to Reduce Inflammation and Boost Beneficial Immune System Function

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Psychotherapy in Addition to Medication Helps Bipolar Disorder Patients Avoid Relapse and Manage Their Symptoms, Study Determines

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Posted: Thursday, November 19, 2020

Psychotherapy in Addition to Medication Helps Bipolar Disorder Patients Avoid Relapse and Manage Their Symptoms, Study Determines

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Unconscious Exposure to a Feared Stimulus Can Reduce Fear, Study Shows

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Posted: Thursday, November 5, 2020

Unconscious Exposure to a Feared Stimulus Can Reduce Fear, Study Shows

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Drugs Targeting the Glutamate System Warrant Continued Development for Schizophrenia, Study Finds

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Posted: Thursday, October 22, 2020

Drugs Targeting the Glutamate System Warrant Continued Development for Schizophrenia, Study Finds

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New Study Demonstrates Non-Invasive tDCS Brain Stimulation Can Enhance Cognitive Control in Schizophrenia Patients

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Posted: Thursday, October 8, 2020

New Study Demonstrates Non-Invasive tDCS Brain Stimulation Can Enhance Cognitive Control in Schizophrenia Patients

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Study Makes Case for Rigorous Re-Testing of Opioid Antagonists to Treat Schizophrenia

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Posted: Thursday, October 1, 2020

Study Makes Case for Rigorous Re-Testing of Opioid Antagonists to Treat Schizophrenia

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Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Posted: Thursday, September 24, 2020

Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Posted: Thursday, August 27, 2020

Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Posted: Tuesday, August 11, 2020

Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Non-Invasive Brain Stimulation Continued to Help Veterans with PTSD a Year After Treatment

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Posted: Wednesday, August 5, 2020

Non-Invasive Brain Stimulation Continued to Help Veterans with PTSD a Year After Treatment

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Non-invasive Brain Stimulation Reduced Fear and Anxiety in a Preliminary Trial

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Posted: Wednesday, July 29, 2020

Non-invasive Brain Stimulation Reduced Fear and Anxiety in a Preliminary Trial

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Identifying Brain Connectivity Changes in Combat Veterans with PTSD

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Posted: Wednesday, July 22, 2020

Identifying Brain Connectivity Changes in Combat Veterans with PTSD

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Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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Posted: Thursday, June 18, 2020

Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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In 2 Trials, Ketamine Plus Behavioral Therapies Helped People with Cocaine and Alcohol Dependencies to Abstain

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Posted: Thursday, May 28, 2020

In 2 Trials, Ketamine Plus Behavioral Therapies Helped People with Cocaine and Alcohol Dependencies to Abstain

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In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Posted: Thursday, May 14, 2020

In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Clinical Trial Measures Impact of Combining Cognitive Training with Drug Treatment in Age-Related Cognitive Decline

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Posted: Thursday, May 7, 2020

Clinical Trial Measures Impact of Combining Cognitive Training with Drug Treatment in Age-Related Cognitive Decline

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Study of Loneliness in a Senior Housing Community Points to Risk and Potential Protective Factors

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Posted: Thursday, April 2, 2020

Study of Loneliness in a Senior Housing Community Points to Risk and Potential Protective Factors

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Progress is Reported on Research Exploring Use of Deep-Brain Stimulation for Psychosis, Schizophrenia

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Posted: Thursday, March 26, 2020

Progress is Reported on Research Exploring Use of Deep-Brain Stimulation for Psychosis, Schizophrenia

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Adding Ambien to an SSRI Antidepressant Could Help Some Depressed Patients with Severe Insomnia

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Posted: Thursday, March 19, 2020

Adding Ambien to an SSRI Antidepressant Could Help Some Depressed Patients with Severe Insomnia

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Activating Specific Serotonin Neurons Reduced Anxiety and Promoted Sleep in Mice

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Posted: Thursday, March 5, 2020

Activating Specific Serotonin Neurons Reduced Anxiety and Promoted Sleep in Mice

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New Approach to Lessen Negative Symptoms in Schizophrenia is Based on Brain Circuit Discovery

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Posted: Thursday, January 16, 2020

New Approach to Lessen Negative Symptoms in Schizophrenia is Based on Brain Circuit Discovery

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Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Posted: Thursday, October 17, 2019

Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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Posted: Thursday, October 10, 2019

Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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Potential Biomarker May Predict Which Depressed Patients Getting CBT Will Have Added Benefit from tDCS Brain Stimulation

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Posted: Thursday, September 26, 2019

Potential Biomarker May Predict Which Depressed Patients Getting CBT Will Have Added Benefit from tDCS Brain Stimulation

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Non-Invasive Brain Stimulation May Help Some OCD Patients Who Don’t Respond to Medications or Psychotherapy

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Posted: Thursday, September 12, 2019

Non-Invasive Brain Stimulation May Help Some OCD Patients Who Don’t Respond to Medications or Psychotherapy

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Large Genome Study Suggests Anorexia Nervosa is a Metabolic Disorder as Well as a Psychiatric One

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Posted: Thursday, August 22, 2019

Large Genome Study Suggests Anorexia Nervosa is a Metabolic Disorder as Well as a Psychiatric One

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Study Finds Lithium Has Advantages Over Other Mood Stabilizers in Youths with Bipolar Disorder

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Posted: Thursday, August 15, 2019

Study Finds Lithium Has Advantages Over Other Mood Stabilizers in Youths with Bipolar Disorder

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