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Depression

Depression

$89M Awarded to Depression Research since 1987

Learn About Depression

The Latest Research Discoveries

Study Links Brain Connectivity Patterns with Responses to an Antidepressant and Placebo

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Posted: Thursday, January 23, 2020

Study Links Brain Connectivity Patterns with Response to Specific Antidepressant and Placebo

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Over Two Decades, 90 BBRF Grants Helped Build a Scientific Foundation for the First Rapid-Acting Antidepressants

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Posted: Tuesday, December 31, 2019

Over Two Decades, 90 BBRF Grants Helped Build a Scientific Foundation for the First Rapid-Acting Antidepressants

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“Restoring a Delicate Balance: Dr. Hilary Blumberg Seeks Ways to Therapeutically Address Subtle Brain Changes that Imaging Has Revealed in Mood Disorders”

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Posted: Tuesday, December 31, 2019

“Restoring a Delicate Balance: Dr. Hilary Blumberg Seeks Ways to Therapeutically Address Subtle Brain Changes that Imaging Has Revealed in Mood Disorders”

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60 year study finds children of mothers who contracted bacterial infection during pregnancy have higher risk of psychosis

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Posted: Thursday, November 14, 2019

After 60 Years, Study Finds Children of Mothers with Bacterial Infections During Pregnancy Have Elevated Psychosis Risk

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Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Posted: Thursday, October 17, 2019

Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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Posted: Thursday, October 10, 2019

Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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Potential Biomarker May Predict Which Depressed Patients Getting CBT Will Have Added Benefit from tDCS Brain Stimulation

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Posted: Thursday, September 26, 2019

Potential Biomarker May Predict Which Depressed Patients Getting CBT Will Have Added Benefit from tDCS Brain Stimulation

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Non-Invasive Brain Stimulation May Help Some OCD Patients Who Don’t Respond to Medications or Psychotherapy

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Posted: Thursday, September 12, 2019

Non-Invasive Brain Stimulation May Help Some OCD Patients Who Don’t Respond to Medications or Psychotherapy

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Researchers Propose a Way to Study the Debilitating Symptoms of Borderline Personality Disorder

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Posted: Thursday, September 5, 2019

Researchers Propose a Way to Study the Underlying Causes of Borderline Personality Disorder

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Early Reductions in Irritability Are Found to Predict Treatment Results in Some Patients with Major Depression

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Posted: Tuesday, July 16, 2019

Early Reductions in Irritability Are Found to Predict Treatment Results in Some Patients with Major Depression

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Brain Scans Reveal a Possible Biomarker for Suicidal Thoughts in PTSD

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Posted: Thursday, May 16, 2019

Brain Scans Reveal a Possible Biomarker for Suicidal Thoughts in PTSD

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Early-Morning Bright-Light Therapy Helped Patients with PTSD Symptoms

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Posted: Wednesday, May 8, 2019

Early-Morning Bright-Light Therapy Helped Patients with PTSD Symptoms

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Study: Ketamine Restores Neural Connection Points Lost in Stress & Depression

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Posted: Thursday, May 2, 2019

Study: Ketamine Restores Neural Connection Points Lost in Stress & Depression

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Different Response Patterns to TMS Therapy Treatment for Major Depression Point to Possibility of Individualized Treatments

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Posted: Thursday, April 25, 2019

Different Response Patterns to TMS Treatment for Major Depression Point to Possibility of Individualized Treatments

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Brain Network Changes May Explain Resilience to Childhood Abuse

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Posted: Monday, April 15, 2019

Brain Network Changes May Explain Resilience to Childhood Abuse

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What Is TMS Treatment and How Well does It Work?

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Posted: Sunday, March 31, 2019

What Is TMS Treatment and How Well does It Work?

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Pioneering TMS Therapy for Depression

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Posted: Sunday, March 31, 2019

Pioneering TMS Therapy for Depression

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Opioids, at Very Low Doses, May Provide a New Way to Treat Resistant Depression

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Posted: Sunday, March 31, 2019

Opioids, at Very Low Doses, May Provide a New Way to Treat Resistant Depression

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The First Drug Treatment To Specifically Relieve Postpartum Depression Is Approved

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Posted: Tuesday, March 26, 2019

The First Drug Treatment To Specifically Relieve Postpartum Depression Is Approved

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A Medicine That Treats Mania Also Shows Effectiveness in Treating Depression in Bipolar Disorder

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Posted: Tuesday, March 19, 2019

A Medicine That Treats Mania Also Shows Effectiveness in Treating Depression in Bipolar Disorder

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Severe Stress Before Age 6 Resulted in Smaller Brain Memory Structures

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Posted: Monday, March 11, 2019

Severe Stress Before Age 6 Resulted in Smaller Brain Memory Structures

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Advisory Panel Recommends FDA Approval of Esketamine , with New Mechanism to Treat Resistant Depression & Suicidal Thinking

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Posted: Thursday, February 14, 2019

Advisory Panel Recommends FDA Approval of Esketamine, with New Mechanism to Treat Resistant Depression

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Researchers Pinpoint Biological Differences Underlying the Way Males and Females Process Fear Memories

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Posted: Tuesday, February 5, 2019

Researchers Pinpoint Biological Differences Underlying the Way Males and Females Process Fear Memories

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Multi-decade Study Found Childhood Trauma Exposure Common, Raising Health Risks in Adulthood

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Posted: Tuesday, January 8, 2019

Multi-decade Study Found Childhood Trauma Exposure Common, Raising Health Risks in Adulthood

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More Rapid Form of Brain Stimulation for Resistant Depression Worked as Well as Conventional TMS

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Posted: Monday, December 3, 2018

More Rapid Form of Brain Stimulation for Resistant Depression Worked as Well as Conventional TMS

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Seeking the Optimal Dose for Ketamine’s Short-Term Rapid Antidepressant Effects

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Posted: Tuesday, November 27, 2018

Seeking the Optimal Dose for Ketamine’s Short-Term Rapid Antidepressant Effects

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New Clues for Medication to Prevent Disorders Caused by Early-Life Stress

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Posted: Tuesday, November 13, 2018

New Clues for Medications to Prevent Disorders Caused by Early-Life Stress

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Researchers Train Computers to Identify a Biological Signature of Bipolar Disorder

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Posted: Monday, October 29, 2018

Researchers Train Computers to Identify a Biological Signature of Bipolar Disorder

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Immune System Factor Could Be Mobilized to Boost Motivation and Cognitive Deficits in Mental Illness

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Posted: Tuesday, October 9, 2018

Boosting Motivation and Cognitive Deficits in Mental Illness

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Researchers Discover That Fast-Acting Antidepressant Ketamine Engages the Body’s Opioid System

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Posted: Tuesday, October 2, 2018

Researchers Discover That Fast-Acting Antidepressant Ketamine Engages the Body’s Opioid System

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Intensive Outpatient Treatment Reduced Vets’ Symptoms of PTSD Within Weeks

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Posted: Monday, September 24, 2018

Intensive Outpatient Treatment Reduced Vets’ Symptoms of PTSD Within Weeks

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A Pacemaker for Depression and More

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Posted: Monday, September 17, 2018

A Pacemaker for Depression and More

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More Articles

Key Figures

300 million

Globally, an estimated 300 million people of all ages suffer from depression.*

* Source: World Health Organization (WHO)

15.7 million adults

In 2014, around 15.7 million adults age 18 or older in the U.S. had experienced at least one major depressive episode in the last year (6.7% of adults in the U.S.).*

* Source: National Institute of Mental Health

2 out of 100

As many as 2 out of 100 young children and 8 out of 100 teens may have serious depression.*

* Source: Anxiety and Depression Association of America (ADAA)

Featured Tweet

A new, more rapid form of transcranial magnetic stimulation holds promise for treating #depression. TWEET

Meet a Researcher

Roland Zahn, M.D., Ph.D.
Read Full Bio
Roland Zahn, M.D., Ph.D.

Reader in the Neurocognitive Bases of Mood Disorders

King’s College London

2016 NARSAD Independent Investigator Grantee

Ask an Expert

Huda Akil, Ph.D. - Brain & behavior research expert on depression
Read the answer
Huda Akil, Ph.D.

Gardner Quarton Distinguished University Professor of Neuroscience and Psychiatry

Co-Director, Molecular and Behavioral Neuroscience Institute

University of Michigan

Scientific Council Member (Joined 2002)

2007 Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience

Question:

In your work with the Pritzker Neuropsychiatric Research Consortium, have you uncovered any new genes that you think might be related to mental illnesses besides major depression?

Donor Stories

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Research Gives People Hope: Multiple family illnesses inspire a couple's life-long commitment to the mental health cause


No one knows better than the Garatt family how far research in mental illness has come – and how far it still has to go. Thirty-three years ago, when...

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A Remarkable Journey


Cindy Warren was diagnosed with depression in 1999 after she attempted suicide. She had seen a therapist off-and-on before then, but her official...

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CNN Features Edi Guyton’s story


Earlier this year, in April, Dr. Sanjay Gupta, Chief Medical Correspondent for ‘CNN Presents,’ produced a special segment on deep brain stimulation (...

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The Strength of My Denial All Those Years


A woman explains why she finally agreed to try deep brain stimulation for her depression. From The Quarterly, Fall 2012 As a Ph.D. who rose to head...

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Nothing To Be Ashamed Of


From a family affected by mental illness, this man supports research to make a difference From The Quarterly, Winter 2013 On February 29, 2000,...

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With Persistence, Recovering from Depression


Staying the course to get the right treatments, and having lots of support, lets this man enjoy his family again From The Quarterly, Fall 2013 Twenty...

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Staving Off “The Darkness”


A Family’s Struggles with Depression and their Good Fortune in Overcoming Its Grip From The Quarterly, Spring 2014 The Peck siblings—Wendy, Amy, and...

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Recovering the Optimistic, Compassionate and Articulate Self Once Lost to Depression


"It isn’t a punishment, it isn’t a weakness,” says Sue Wright, speaking about her depression. She is proof, she says, that depression is a mental...

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Finding a Way to Help and Heal


An Annual Event Honors a Beloved Son and Supports the Foundation’s Research Toward the end of his freshman year at the University of Minnesota, where...

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