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Depression

Depression

$89M Awarded to Depression Research since 1987

Learn About Depression

The Latest Research Discoveries

Positive Phase 3 Test of Rapid-Acting Oral Medicine for Postpartum Depression

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Posted: Wednesday, July 14, 2021

Positive Phase 3 Test of Rapid-Acting Oral Medicine for Postpartum Depression

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Positive Results in Trial Testing ‘Laughing Gas’ in Severely Depressed Treatment-Resistant Patients

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Posted: Thursday, June 17, 2021

Positive Results in Trial Testing ‘Laughing Gas’ in Severely Depressed Treatment-Resistant Patients

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Postpartum CBT for Depressed Moms May Help Lower Emotion-Regulation Risks in Infants

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Posted: Thursday, June 10, 2021

Postpartum CBT for Depressed Moms May Help Lower Emotion-Regulation Risks in Infants

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Medicine to Treat Premenstrual Mood Disorder is Tested

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Posted: Thursday, May 6, 2021

Medicine to Treat Premenstrual Mood Disorder is Tested

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Study Points to Importance of Cognitive Inflexibility in Children Diagnosed with Bipolar Disorder

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Posted: Thursday, April 29, 2021

Study Points to Importance of Cognitive Flexibility in Children Diagnosed with Bipolar Disorder

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Largest Genome Study to Date of Anxiety Reveals New Risk Variants and Suggests Possible Biological Mechanisms

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Posted: Thursday, April 22, 2021

Largest Genome Study to Date of Anxiety Reveals New Risk Variants and Suggests Possible Biological Mechanisms

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In Major Depression, Accelerated rTMS Brain Stimulation Shows Promise

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Posted: Thursday, March 11, 2021

In Major Depression, Accelerated rTMS Brain Stimulation Shows Promise

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Team Reports on Search for Genetic Subgroups Within Depression

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Posted: Thursday, December 3, 2020

Team Reports on Search for Genetic Subgroups Within Depression

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Study Reveals Adults With Mental Disorders Are At Significantly Higher Risk of COVID-19 and Have Poorer Outcomes

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Posted: Thursday, November 12, 2020

Study Reveals Adults With Mental Disorders Are At Significantly Higher Risk of COVID-19 and Have Poorer Outcomes

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Researchers Discover a Role for Immune Cells Called Microglia in Inhibiting Brain Activity and Regulating Behavior

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Posted: Thursday, October 29, 2020

Researchers Discover a Role for Immune Cells Called Microglia in Inhibiting Brain Activity and Regulating Behavior

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Study of Seniors With Depression Shows How They Are Dealing With the COVID-19 Pandemic

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Posted: Thursday, October 15, 2020

Study of Seniors With Depression Shows How They Are Dealing With the COVID-19 Pandemic

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Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Posted: Thursday, September 24, 2020

Team Discovers Mechanism in Blood-Vessel Cells in the Brain That Promotes Resilience Against Stress

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Large Genetic Study Expands Links Between DNA Variations and Problematic Drinking

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Posted: Thursday, September 17, 2020

Large Genetic Study Expands Links Between DNA Variations and Problematic Drinking

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Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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Posted: Thursday, August 27, 2020

Magnetic Seizure Therapy (MST) Shows Promise as Possible Alternative to ECT for Reducing Major Depression and Suicidality

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How the Brain’s Reward System Goes Awry in Depression Affecting Young People

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Posted: Thursday, August 13, 2020

How the Brain’s Reward System Goes Awry in Depression Affecting Young People

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Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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Posted: Tuesday, August 11, 2020

Remarkable Results in a Preliminary Clinical Test of a Rapid-Acting Antidepressant Treatment

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New Insights About How Alcohol Withdrawal Changes the Brain Differently in Males and Females

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Posted: Thursday, June 25, 2020

New Insights About How Alcohol Withdrawal Changes the Brain Differently in Males and Females

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Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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Posted: Thursday, June 18, 2020

Remarkable Improvement Rate Reported in Patients Who Received SAINT, an Experimental Non-Invasive Brain-Stimulation Treatment for Resistant Depression

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Brain-wave EEG Signature Robustly Predicted Antidepressant Response

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Posted: Thursday, June 11, 2020

Brain-wave EEG Signature Robustly Predicted Antidepressant Response

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In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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Posted: Thursday, May 14, 2020

In a Surprising Clinical Trial, Ketamine’s Antidepressant Effects Lasted Longer

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https://www.bbrfoundation.org/sites/default/files/field/image/sadworriedyoungwoman-2-1440.jpg

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Posted: Thursday, April 30, 2020

Brain Activity While Anticipating a Working-Memory Task Could Help Distinguish Depression in Bipolar Disorder from Major Depression

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Study of Loneliness in a Senior Housing Community Points to Risk and Potential Protective Factors

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Posted: Thursday, April 2, 2020

Study of Loneliness in a Senior Housing Community Points to Risk and Potential Protective Factors

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Adding Ambien to an SSRI Antidepressant Could Help Some Depressed Patients with Severe Insomnia

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Posted: Thursday, March 19, 2020

Adding Ambien to an SSRI Antidepressant Could Help Some Depressed Patients with Severe Insomnia

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Problems in Early Life Leave Biological Traces in Depressed Moms That May Impair Bonding With Their Babies

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Posted: Friday, March 13, 2020

Problems in Early Life Leave Biological Traces in Depressed Moms That May Impair Bonding With Their Babies

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Activating Specific Serotonin Neurons Reduced Anxiety and Promoted Sleep in Mice

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Posted: Thursday, March 5, 2020

Activating Specific Serotonin Neurons Reduced Anxiety and Promoted Sleep in Mice

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Impact of Electronic Media Use on Mental Health in Children

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Posted: Thursday, February 27, 2020

Study Finds “Small But Significant” Impact of Electronic Media Use on Mental Health in Children

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Impact of Mother’s Depressive Symptoms Just Before and After Childbirth Upon Child’s Brain Development

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Posted: Thursday, January 30, 2020

Impact of Mother’s Depressive Symptoms Just Before and After Childbirth Upon Child’s Brain Development

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Study Links Brain Connectivity Patterns with Response to Specific Antidepressant and Placebo

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Posted: Thursday, January 23, 2020

Study Links Brain Connectivity Patterns with Response to Specific Antidepressant and Placebo

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Over Two Decades, 90 BBRF Grants Helped Build a Scientific Foundation for the First Rapid-Acting Antidepressants

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Posted: Tuesday, December 31, 2019

Over Two Decades, 90 BBRF Grants Helped Build a Scientific Foundation for the First Rapid-Acting Antidepressants

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60 year study finds children of mothers who contracted bacterial infection during pregnancy have higher risk of psychosis

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Posted: Thursday, November 14, 2019

After 60 Years, Study Finds Children of Mothers with Bacterial Infections During Pregnancy Have Elevated Psychosis Risk

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Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Posted: Thursday, October 17, 2019

Deep-Brain Stimulation Showed Multi-Year Effectiveness in Severely Depressed, Treatment-Resistant Patients

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Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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Posted: Thursday, October 10, 2019

Fatty Acid Levels in the Brain Are Found to Correlate With Serotonin Transport and Depression Severity

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More Articles

Key Figures

300 million

Globally, an estimated 300 million people of all ages suffer from depression.*

* Source: World Health Organization (WHO)

15.7 million adults

In 2014, around 15.7 million adults age 18 or older in the U.S. had experienced at least one major depressive episode in the last year (6.7% of adults in the U.S.).*

* Source: National Institute of Mental Health

2 out of 100

As many as 2 out of 100 young children and 8 out of 100 teens may have serious depression.*

* Source: Anxiety and Depression Association of America (ADAA)

Featured Tweet

A new, more rapid form of transcranial magnetic stimulation holds promise for treating #depression. TWEET

Meet a Researcher

Peter Nagele, M.D.
Read Full Bio
Peter Nagele, M.D.

Chair, Department of Anesthesia and Critical Care

University of Chicago

2016 Independent Investigator Grant

Ask an Expert

Huda Akil, Ph.D. - Brain & behavior research expert on depression
Read the answer
Huda Akil, Ph.D.

Gardner Quarton Distinguished University Professor of Neuroscience and Psychiatry

Co-Director, Molecular and Behavioral Neuroscience Institute

University of Michigan

2007 Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience

Question:

In your work with the Pritzker Neuropsychiatric Research Consortium, have you uncovered any new genes that you think might be related to mental illnesses besides major depression?

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