Investigating Neurobiology and New Treatments for Addiction, Depression and Anxiety

Dr. Addy’s research focuses on the neurobiology of motivational control, reward behavior, and reinforcement learning. He seeks to identify how these brain processes are altered in substance use disorders, depression and anxiety. Dr. Addy’s work incorporates various methods including the use of preclinical rodent models, electrochemistry, cellular and molecular biology, and electrophysiology. His lab has identified neurotransmitter mechanisms, namely dopamine and acetylcholine interactions, in specific brain pathways that regulate drug-relapse behavior and responses to stress and anxiety. His lab also examines neurotransmitter receptors and calcium channels that may serve as therapeutic targets to treat substance use and mood disorders. As part of the Yale Tobacco Center for Regulatory Science (TCORS), Dr. Addy’s team examines the effects of tobacco product flavors on nicotine reward and aversion, and on nicotine use behavior. In addition to basic science research, Dr.