Ketamine: Why Now? How? Where Do We Go from Here?

Tuesday, June 12, 2018, 2:00 pm EDT
Meet the Scientist - June 2018

Can the fast-acting antidepressant ketamine help people with PTSD? Scientists theorize that traumatic stress impairs the integrity of connections between nerve cells in the brain, leading to a variety of often debilitating problems, including those experienced by people with PTSD. Dr. Krystal explores the possibility of restoring damaged neural connections to provide relief for patients.

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Presented by 
John H. Krystal, M.D.
John H. Krystal, M.D.
Yale University School of Medicine

Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry and of Neuroscience

Chair, Department of Psychiatry,

Chief of Psychiatry and Behavioral Health, Yale-New Haven Hospital

Director, Clinical Neuroscience Division, VA National Center for PTSD

Director: NIAAA Center for the Translational Neuroscience of Alcoholism

Scientific Council Member (Joined 2003)

2019 Colvin Prizewinner for Outstanding Achievement in Mood Disorders Research

2006, 2000 Distinguished Investigator Grant

1997 Independent Investigator Grant

Dr. John H. Krystal is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizo-phrenia, and depression. His work links psychophar-macology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobi-ology and treatment of these disorders. He is best known for leading the discovery of the rapid antide-pressant effects of ketamine in depressed patients.

In the 1990s, Dr. Krystal’s mentor and colleague, Dr. Dennis Charney, found reason to question the centrality of monoamines to depression. This led them to hypothesize that the signaling mechanisms employed by higher brain centers, particularly glutamate and GABA signaling, might be critical to depression and its treatment.

Moderated by 
Jeffrey Borenstein, M.D.
Brain & Behavior Research Foundation

President and CEO

Jeffrey Borenstein, M.D., serves as the President & CEO of the Brain & Behavior Research Foundation, the largest private funder of mental health research grants. Dr. Borenstein developed the Emmy Award-nominated public television program “Healthy Minds,” and serves as host of the series. The program, which is broadcast nationwide, focuses on topics in psychiatry in order to educate the public, reduce stigma and offer a message of hope. Dr. Borenstein also serves as Editor-in-Chief of Psychiatric News, the newspaper of the American Psychiatric Association and as an Associate Clinical Professor of Psychiatry at Columbia University College of Physicians and Surgeons.