Bipolar depressive episodes are the main burden for people with bipolar disorder. People with a history of mania experience bipolar depressive episodes or symptoms about a third of the time, while those with a history of hypomania can experience them more than half the time. Antidepressants in general have not been shown to be better than placebo, yet they remain the most common treatments. Dr. Nierenberg will review other existing and potential treatments, including ECT; non-invasive brain stimulation (rTMS); ketamine and esketamine; lamotrigine; and cognitive behavioral therapy and family-focused therapy.
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