Widely Prescribed Stimulants and the Risk of Psychosis in Young People with ADHD

Tuesday, July 14, 2020, 2:00 pm EDT
Meet the Scientist - July 2020

The prescription use of stimulants such as Ritalin and Adderall (methylphenidate and amphetamine, respectively) for the treatment of ADHD has been increasing. In 2007, the FDA mandated changes to drug labels for stimulants, based on findings about increased risk for psychosis. We studied whether the risk of psychosis in patients with ADHD differs among various stimulant types and found that patients prescribed amphetamine were at a higher risk of new psychosis requiring treatment with antipsychotic medicines than patients who had been prescribed methylphenidate.

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Presented by 
Lauren Moran, M.D.
Lauren Moran, M.D.
Harvard Medical School / McLean Hospital

Assistant Professor, Department of Psychiatry

Psychiatrist in Charge, Schizophrenia and Bipolar Disorder Inpatient Program

2013 Young Investigator Grant

Lauren V. Moran, MD, is an attending psychiatrist with the Schizophrenia and Bipolar Disorder Inpatient Program. Her current research focus is on evaluating the role of prescription stimulants in the development of psychotic disorders. Dr. Moran also conducts research on understanding the neurobiology of high rates of nicotine dependence in patients with schizophrenia.

Moderated by 
Jeffrey Borenstein, M.D.
Brain & Behavior Research Foundation

President and CEO

Jeffrey Borenstein, M.D., serves as the President & CEO of the Brain & Behavior Research Foundation, the largest private funder of mental health research grants. Dr. Borenstein developed the Emmy Award-nominated public television program “Healthy Minds,” and serves as host of the series. The program, which is broadcast nationwide, focuses on topics in psychiatry in order to educate the public, reduce stigma and offer a message of hope. Dr. Borenstein also serves as Editor-in-Chief of Psychiatric News, the newspaper of the American Psychiatric Association and as an Associate Clinical Professor of Psychiatry at Columbia University College of Physicians and Surgeons.