Scientific Council Member
David A. Lewis, M.D.
David A. Lewis, M.D.
UPMC Endowed Professor in Translational Neuroscience
Chairman, Department of Psychiatry
Medical Director and Director of Research, Western Psychiatric Institute and Clinic
Director, Translational Neuroscience Program
Director, NIMH Conte Center for Translational Mental Health Research
2008 Distinguished Investigator Grantee
2005 Lieber Prizewinner for Outstanding Achievement in Schizophrenia Research
Dr. Lewis aims to define the processes that give rise to the cognitive deficits of schizophrenia by studying the neural circuitry of certain brain regions, with the goal of identifying potential targets for therapeutic interventions. His team is characterizing the development of normal prefrontal cortex circuitry in the macaque monkey, specifically examining events that occur during childhood and adolescence for their possible contribution to the emergence of cognitive disturbances of schizophrenia. The team then generates hypotheses regarding elements of neural circuitry that are dysfunctional in schizophrenia and tests them in postmortem brain specimens from patients with schizophrenia. The results are used to identify novel drug targets that are then tested in proof-of-concept clinical trials.
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