Dr. Goldstein is the Mount Sinai Professor in Neuroimaging and Addiction at the Department of Psychiatry with a secondary appointment at the Department of Neuroscience/Friedman Brain Institute (FBI) in the Icahn School of Medicine at Mount Sinai (ISMMS). Dr. Goldstein directs the Neuroimaging of Addictions and Related Conditions (NARC) Research Program, and previously the Brain Imaging Center (BIC) at ISMMS, both internationally recognized for their use and development of innovative multimodality neuroimaging methods (including MRI, PET, EEG/ERP) for the translational study of brain morphology and function.

Nationally and internationally known for her neuroimaging and neuropsychological studies in drug addiction, Dr. Goldstein formulated a theoretical model known as Impaired Response Inhibition and Salience Attribution (iRISA). Multiple neuroimaging modalities—including MRI, EEG/ERP, PET—and neuropsychological tests are used to explore the neurobiological underpinnings of iRISA in drug addiction and related conditions. This model has drawn considerable scientific attention (exceeding 3,000 citations for a review published in the Am J Psychiatry in 2002 and 2,000 for another review published in Nature Reviews Neuroscience in 2011). An important application of Dr. Goldstein’s research is to facilitate the development of intervention modalities that would improve cognitive and emotional function, leading to better treatment outcomes, in drug addiction and other chronically relapsing disorders of self-regulation.