Studies from Dr. Duman’s laboratory have contributed to the characterization of the molecular and cellular actions of antidepressants and stress, providing the basis for a neurotrophic hypothesis of depression. Dr. Duman’s research has shown that antidepressants increase the growth and survival of new neurons and glia, which he believes may explain in part how these drugs produce their therapeutic effects. These findings represent major advances in the understanding of the effects of antidepressants and provide a framework for the development of novel therapeutic agents.

Dr. Duman conducted postgraduate work at Yale University before joining the Yale faculty.