It is now almost 15 years since researchers first used a method called Deep Brain Stimulation (DBS) to treat major depression that has not responded to conventional therapies. Subsequently, follow-up studies have made steady progress, both technically, in terms of how the treatment is targeted in the brain, as well as in identifying which patients are most likely to benefit. Close monitoring of patients has improved our ability to understand effects of DBS over the long-term, and to link these with changes at the level of neural circuits. This work brings us ever closer to a more comprehensive understanding of illness and recovery.
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