By inhibiting a previously untargeted nerve-cell receptor in the brain, researchers have discovered a new class of compounds that may be useful in the treatment of schizophrenia.
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An area of the forebrain called the basal ganglia helps people to decide which actions to take—should I eat this apple?—and whether the action had a good (the apple was tasty) or bad (the apple was rotten) outcome.
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Two new small-molecule compounds tested in mice can alleviate some symptoms of schizophrenia-like behaviors, including movement abnormalities, social avoidance, and cognitive performance.
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