Depression

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Accelerating Psychiatric Drug Development

Our PATHWAYS TO THE FUTURE story is about an unconventional approach to developing new psychiatric drugs. Based on an initiative by the National Institute of Mental Health, it’s called “Fast-Fail” and is designed to weed out the weakest drug candidates early in the process, to save time and money. In its first comprehensive test, a team led by two BBRF grantees and including 11 other BBRF grantees, Scientific Council members and prize winners, demonstrated the approach using a potential drug to treat anhedonia—the inability to experience or seek pleasure—which is seen in a number of psychiatric disorders including depression, anxiety, and PTSD.

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‘An Epidemic of Loneliness and Despair’: How Wisdom Can Help

Q&A with Dilip Jeste, M.D., on the role of wisdom in dealing with what he has called “an epidemic of loneliness and despair” in America.

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How to Deal with Holiday Stress during Covid-19

The holiday season usually is a joyful time. Many families look forward to gathering with relatives and friends, exchanging gifts, and celebrating traditions. In a normal year, the holidays can even be a bit stressful.

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RESILIENCE: A Q&A with Dr. Dennis S. Charney

A World Expert Discusses What Research and Personal Experience Have Taught Him

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A Strong Impulse to Help People Who  Live with Mental Illness Propels a Diverse Career in Clinical Brain Research

Deanna Barch, Ph.D., a much honored research scientist who now chairs the department of Psychological and Brain Sciences at Washington University in St. Louis, did not take long in life to discover her passion.

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