A stem cell-based technology provides a unique window on illnesses such as autism and schizophrenia.
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Dr. Dawn Velligan discusses ways in which she helps schizophrenia patients handle symptoms that are not resolved by medications.
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Dr. Vikaas Sohal and colleagues have used advanced technologies to discover biological processes that are likely involved in causing cognitive dysfunction in schizophrenia. The road to bold new treatments is being paved with this new knowledge.
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A story about the research of Dr. Kristen Brennand, which 20 years ago might have sounded like science fiction: taking skin or blood cells harmlessly sampled from psychiatric patients, reprogramming them to a stem-cell-like state, and then directing them to redevelop in culture dishes as brain cells. This technology is enabling scientists to observe pathology as it emerges in cells that bear patients’ precise genetic sequence. It’s especially valuable in illnesses like schizophrenia and autism that have deep genetic roots which have been linked to abnormalities that may begin at the dawn of life, when the brain is just beginning to form.
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