Depression

Brain Matters
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2022 Leading Research Achievements
We are pleased to present you with the 2022 Leading Research Achievements by BBRF Grantees, Prizewinners & Scientific Council Members. Read More
A Q&A with Dr. Mark S. George on Brain Stimulation for Psychiatric Illness

Dr. George, a pioneer in the field, answers practical questions about TMS and other brain stimulation therapies for psychiatric illness.

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A RESEARCHER'S PERSPECTIVE: We Are Witnessing a Revolution in Brain Stimulation

Dr. Mark S. George, a pioneer in the field, explains how TMS and related non-invasive brain stimulation technologies are changing the face of psychiatry.

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Highly Individualized Deep-Brain Stimulation Helps a Patient With Severe Treatment-Resistant Depression

We write about a novel idea to address brain-based disorders that has moved from theory to bedside in only 3 years. Called closed-loop neuromodulation, it involves using electrical stimulation—delivered via an implanted deep-brain stimulation (DBS) device—at a precise location in the brain. The stimulation occurs intermittently throughout each day for only seconds at a time, and only at moments when a sensor placed in another part of the brain detects a specific EEG brain-wave pattern linked with the onset of a patient’s depressed moods.  In its first clinical test, a treatment-resistant patient experienced a remission.

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Studying Ketamine’s Rapid Effects to Unlock Secrets for Developing Better Antidepressants

We offer A RESEARCHER’S PERSPECTIVE, based on a presentation given by Lisa M. Monteggia, Ph.D., of Vanderbilt University, at a zoom event hosted by BBRF. The topic of her presentation was “Studying Ketamine’s Rapid Effects to Unlock Secrets for Developing Better Antidepressants.” Dr. Monteggia reflects on what she has learned about antidepressant mechanisms from the therapeutic results obtained with the experimental drug ketamine.

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