We write about a novel idea to address brain-based disorders that has moved from theory to bedside in only 3 years. Called closed-loop neuromodulation, it involves using electrical stimulation—delivered via an implanted deep-brain stimulation (DBS) device—at a precise location in the brain. The stimulation occurs intermittently throughout each day for only seconds at a time, and only at moments when a sensor placed in another part of the brain detects a specific EEG brain-wave pattern linked with the onset of a patient’s depressed moods. In its first clinical test, a treatment-resistant patient experienced a remission.
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We offer A RESEARCHER’S PERSPECTIVE, based on a presentation given by Lisa M. Monteggia, Ph.D., of Vanderbilt University, at a zoom event hosted by BBRF. The topic of her presentation was “Studying Ketamine’s Rapid Effects to Unlock Secrets for Developing Better Antidepressants.” Dr. Monteggia reflects on what she has learned about antidepressant mechanisms from the therapeutic results obtained with the experimental drug ketamine.
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Our PATHWAYS TO THE FUTURE story is about an unconventional approach to developing new psychiatric drugs. Based on an initiative by the National Institute of Mental Health, it’s called “Fast-Fail” and is designed to weed out the weakest drug candidates early in the process, to save time and money. In its first comprehensive test, a team led by two BBRF grantees and including 11 other BBRF grantees, Scientific Council members and prize winners, demonstrated the approach using a potential drug to treat anhedonia—the inability to experience or seek pleasure—which is seen in a number of psychiatric disorders including depression, anxiety, and PTSD.
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Q&A with Dilip Jeste, M.D., on the role of wisdom in dealing with what he has called “an epidemic of loneliness and despair” in America.
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The holiday season usually is a joyful time. Many families look forward to gathering with relatives and friends, exchanging gifts, and celebrating traditions. In a normal year, the holidays can even be a bit stressful.
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